What it is
Semax is a synthetic heptapeptide derived from the ACTH(4-10) fragment, developed in Russia, where it is registered as a nootropic and neuroprotective agent. It has no hormonal (corticotropic) activity.
Mechanism
Semax increases the expression of brain-derived neurotrophic factor (BDNF) and its receptor TrkB, modulates the serotonergic and dopaminergic systems, and shows antioxidant and anti-inflammatory activity in ischaemia models. It is typically studied via intranasal delivery because of rapid brain uptake.
Research areas
- Cognitive performance, attention and memory
- Neuroprotection in stroke and ischaemia models
- BDNF signalling
- Anxiety and stress adaptation
- Optic-nerve and neuropathy models
Safety and metabolism
Decades of clinical use in Russia with a favourable safety profile. Rapidly degraded by peptidases; short half-life.
Why this amount
10 mg is the standard research vial and the basis for the upcoming nasal-spray format.
